Planta Med 2002; 68(2): 142-145
DOI: 10.1055/s-2002-20260
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Butanolides and Secobutanolides from the Stem Wood of Formosan Lindera communis

Ian-Lih Tsai1 , Chao-Hui Hung1 , Chang-Yih Duh2 , Ih-Sheng Chen1
  • 1Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
  • 2Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, R.O.C.
Further Information

Publication History

March 1, 2001

June 30, 2001

Publication Date:
22 February 2002 (online)

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Abstract

Bioassay-guided fractionation of the chloroform-soluble fraction from the stem wood of Formosan Lindera communis led to the isolation of two new cytotoxic butanolides, lincomolide C (1), lincomolide D (2), as well as two new secobutanolides, secolincomolide A (3), secolincomolide B (4), together with four known compounds, including one butanolide, isoobtusilactone A (5), and one secobutanolide, secoisolancifolide (6), one sesquiterpene, epi-cubenol (7), one steroid: β-sitosterol (8). Compound 4 existed in enol {(2E)-2-[(1R)-1-hydroxy-2-oxo-propyl]-6,9-dimethyl-8-hydroxy-hexadec-2,7-dienoic acid methyl ester} (4a) and keto {(2E)-2-[(1R)-1-hydroxy-2-oxo-propyl]-6,9-dimethyl-8-oxo-hexadec-2-enoic acid methyl ester} (4b) tautomers. Compound 2 showed significant cytotoxicity against P-388 and HT-29 cancer cell lines. Also, 2 exhibited marginal activity against A549, 5 against P-388, and 1 against P-388, A549 and HT-29 cancer cell lines. Their structures were determined by spectroscopic analyses.

References

Prof. Dr. Ian-Lih Tsai

School of Pharmacy

College of Pharmacy

Kaohsiung Medical University

Kaohsiung

Taiwan

Republic of China

Email: ialits@kmu.edu.tw

Fax: +886-7-321-0683